Over the last few months (and in coming months), we’ve presented a series of protocols for genotyping and DNA isolation in a variety of model organisms. Much of this material was adapted in advance from Genetic Variation: A Laboratory Manual, which is now available from CSHL Press. It’s a difficult subject for a laboratory manual, as it’s such a rapidly advancing field, and the question when it was proposed was, is it possible to put together a manual that isn’t obsolete the moment it’s published? Read the rest of this entry »

September’s issue of CSH Protocols is upon us (my, that was a quick summer–Kurt Weill sure knew what he was talking about). We’re featuring two protocols this month, both available freely to non-subscribers (as are all of our sample protocols). The first is for generating mouse models for squamous cell carcinoma and the second is for the Oligonucleotide Ligation Assay (OLA), used for finding Single-Nucleotide Polymorphisms (SNP’s). Read the rest of this entry »

The July issue of CSH Protocols is available and features a set of articles detailing the basics for common Bioinformatics techniques (and just in time for the 4th of July, allowing me to make a “blast” pun). Read the rest of this entry »

Recently, the New York Times featured an article on the growing controversy over Oxford geneticist Stephen Oppenheimer’s work on the genetic makeup of the British Isles. While the common belief is that the English come from the Anglo-Saxons and the rest of the population of the British Isles come from the Celts and a few others, Oppenheimer’s work points towards a more common ancestry for all groups. Read the rest of this entry »